Dogs  -  CANVAC 8 DHPPiL

CANVAC 8 DHPPiL inj. sicc. ad us. vet.

Selected mammalians
1.0 ml s. c.
Product characteristics
The product CANVAC 8 DHPPiL is a polyvalent vaccine against distemper, infectious hepatitis, infectious laryngotracheitis, parvovirosis, parainfluenza and leptospira icterohaemorrhagiae, grippotyphosa and sejroe.
Dosage form
An injectable solution for parenteral administration which originates via reconstitution of the lyophilized constituent in the liquid constituent or the relevant diluent. 
Qualitative and quantitative composition
Each one vaccination dose of the product contains:
Active ingredients: 
virus febris contagiosae canis attenuatum at an amount of NLT 102.7 KEID50;
virus laryngotracheitidis contagiosae canis attenuatum at an amount of NLT 103.5 TCID50;
parvovirus enteritidis canis attenuatum at an amount of NLT 128 HAU;
virus parainfluensis canis attenuatum at an amount of NLT 103.0 TCID50 ;
leptospira icterohaemorrhagiae inactivata, leptospira grippotyphosa inactivata and leptospira sejroe inactivata at amounts which induce a serological response in experimental animals at NLT the 1 : 32 titer of specific antibodies;
Inactive ingredients: 
lyophilization medium ad 1.0 ml;
diluent of the vaccine: aqua pro inj. 1.0 ml.
Animal species to be treated with the product
Dogs, canine and musteline animals and fur-coat animals
A dose per  1 animal is 1.0 ml irrespective of  animal species, age and weight.
In live valences, the vaccine is safe even at a ten-fold dose, while in inactivated valences it is safe at a doubled dose.
Route of administration
Dissolve the lyophilizate of the vaccine in 1.0 ml of the diluent immediately prior to use. The contents of the medicinal bottle must be thoroughly dissolved before administration. The vaccine should be administered subcutaneously, best of all at the area behind the scapula. 
The vaccination schedule must be defined by the veterinary surgeon. 
When youngsters are to be vaccinated, the level of immunity of mothers must be taken into account (i.e. whether or not mothers have been immunized). It is advisable to revaccinate the vaccinated animals younger than 4 months (approximately over two to three weeks). In order to minimize an undesirable influence of the colostral immunity in pups, animals may be re-vaccinated repeatedly at three-week intervals. For the maintenance of  lasting immunity, an annual revaccination on a regular basis is recommended. 
The vaccine is designed for the active immunization of dogs and canine animals against distemper, infectious hepatitis, infectious laryngotracheitis of dogs, parvovirosis of dogs, and parainfluenza of dogs.
Vaccination represents a general immunobiological stress for an animal being immunized, and hence it should be used in healthy animals only. Therefore, it is contraindicated particularly in the following cases: 
- acute infectious diseases,
- organ and feverish diseases, and in cases when an adverse post-vaccination reaction or allergy to former vaccinations were ascertained in animals, 
- after a stress to which animals were exposed (transportation, high temperatures of  the environment).   
The vaccine must not be used in cases of running infections against which the vaccine is designed, and it must not be implemented simultaneously with passive immunization of animals, i.e. on parenteral administration of specific antibodies.
Adverse drug reactions
Infrequently, the administration of the vaccine may  induce a slight sub-febrile increase in temperature and transient inappetence; in rare cases, after a previous sensitization, an anaphylactic reactions may occur.
The vaccine against rabies CANVAC R inj. ad us. vet. may be used as a diluent of this vaccine. 
Pregnancy and lactation
Besides common and infrequent reactions, no risks of vaccination of pregnant females or females after parturition are known. Despite this fact, generally, it is not recommended to vaccinate animals at late stages of pregnancy and closely after parturition. 
The vaccine may be used at early and medium stages of pregnancy and in nursing mothers at the period of lactation.
The vaccination of mothers and the level of their immunity have an essential influence on protection of their offspring  by means of colostral immunity. Specific antibodies are passed to youngsters with colostrum. These antibodies exert no undesirable effects on the young animal.
Withdrawal periods
None. The vaccine is environmentally friendly.
How supplied
Type of package:
Glass or plastic medicinal bottles are closed with a rubber stopper and an aluminum torque collar, provided with a label and  placed in a carton box together with a package information leaflet.  
Size of package:
1.0 ml of the lyophilized suspension in a 3-ml medicinal bottle;
1.0 ml of the diluent in a 3-ml medicinal bottle, 
i.e. 1 dose. 
6 doses, i.e. 6 medicinal bottles of the lyophilizate and 6 medicinal bottles of the diluent, are placed in 1 carton box.
30 doses, i.e. 30 medicinal bottles of the lyophilizate and 30 medicinal bottles of the diluent, are placed in 1 plastic box.
The product must be completely used until expiration of the shelf-life indicated on the label of each medicinal bottle, i.e. within 18 months from the date of manufacture. The product must not be used after expiration of the shelf-life. The vaccine must be fully used immediately after its reconstitution.
In a dry and dark place, at temperatures between 2 and 8 °C
Special precautions
The route of vaccination and the vaccination schedule in fur-coat animals depends on a decision made by the veterinary surgeon. 
In very rare cases, fur-coat animals may produce a generally adverse reaction to live valences of the vaccine. If ferrets are to be vaccinated, higher caution is necessary after administration of the vaccine owing to their enhanced susceptibility  to the attenuated virus of distemper.
After vaccination, it is advisable to leave animals at rest for 2 to 3 days. It is especially recommended to avoid training, hunting or other strenuous activities in dogs.  It is also recommended  to avoid shifting of animals or their exposure to stress conditions. Youngsters should be left at rest for approximately 1 week. 
It is recommended to immunize de-wormed animals.